2019–20 U.C. Sampdoria season

The 2019–20 season is Unione Calcio Sampdoria's 63rd season in Serie A, and their 8th consecutive season in the top-flight. The club are competing in Serie A and the Coppa Italia.

Former Sassuolo and Roma coach Eusebio Di Francesco replaced Marco Giampaolo as head coach on 22 June 2019, with Giampaolo moving to Milan on 19 June.