2019 Africa Cup of Nations knockout stage

The knockout stage of the 2019 Africa Cup of Nations is the second and final stage of the competition, following the group stage. It will begin on 5 July with the round of 16 and end on 19 July 2019 with the final, held at the Cairo International Stadium in Cairo. A total of 16 teams (the top two teams from each group, along with the four best third-placed teams) advanced to the knockout stage to compete in a single-elimination style tournament.

All match times are local, CAT (UTC+2).

Format
In the knockout stage, except for the third place play-off, if a match is level at the end of 90 minutes of normal playing time, extra time will be played (two periods of 15 minutes each). If still tied after extra time, the match will be decided by a penalty shoot-out to determine the winner. In the third place play-off, if the scores remain level after 90 minutes the match will go directly to a penalty shoot-out, without any extra time being played.

CAF set out the following schedule for the round of 16:
 * Match 37: Winner Group B v 3rd Group A/C/D
 * Match 38: Runner-up Group A v Runner-up Group C
 * Match 39: Winner Group A v 3rd Group C/D/E
 * Match 40: Winner Group C v 3rd Group A/B/F
 * Match 41: Winner Group D v 3rd Group B/E/F
 * Match 42: Runner-up Group B v Runner-up Group F
 * Match 43: Winner Group E v Runner-up Group D
 * Match 44: Winner Group F v Runner-up Group E

Combinations of matches in the round of 16
The specific match-ups involving the third-placed teams depend on which four third-placed teams qualified for the round of 16:

Qualified teams
The top two placed teams from each of the six groups, plus the four best-placed third teams, will qualify for the knockout stage.